Aubergine intolerance, also known as eggplant intolerance in some regions, is a condition that reflects difficulty in digesting aubergine. Unlike an aubergine allergy, which involves an immune system response and can trigger more severe reactions, intolerance primarily leads to gastrointestinal discomfort. People with aubergine intolerance typically experience digestive symptoms after consuming aubergine.

Cabbage intolerance refers to difficulty digesting cabbage, often resulting in gastrointestinal discomfort. Unlike a cabbage allergy, which triggers an immune reaction, this intolerance is related to digestion and typically causes symptoms after eating cabbage.

Herring intolerance is a condition in which the body has difficulty digesting herring, often leading to gastrointestinal discomfort. Unlike a herring allergy, which involves an immune response and can cause severe reactions, herring intolerance is typically limited to digestive symptoms after eating this type of fish.

Chamomile tea intolerance is a condition that reflects difficulty in digesting chamomile tea, an herbal infusion made from dried chamomile flowers. Unlike a chamomile tea allergy, which triggers an immune response and can cause more severe reactions, intolerance mainly leads to digestive discomfort. People with chamomile tea intolerance typically experience gastrointestinal symptoms after consuming chamomile tea.

Acarus siro, commonly known as the flour mite, is a species often found in stored grains and flour. These mites can thrive in kitchen cupboards and pantries, particularly in humid conditions. For sensitive individuals, exposure may trigger allergic symptoms and can be especially problematic for those with existing respiratory conditions.

Honey intolerance is a condition in which individuals have difficulty digesting honey, a natural sweetener produced by bees. It can cause gastrointestinal discomfort and is distinct from a honey allergy, which involves an immune reaction and may trigger more severe symptoms. People with honey intolerance typically experience digestive issues after consuming honey or products containing it.

LDL (Low-Density Lipoprotein) is a type of cholesterol often referred to as “bad” cholesterol. It carries cholesterol particles through the bloodstream, and high levels can contribute to plaque buildup in the arteries. This buildup, known as atherosclerosis, can narrow and stiffen arteries, increasing the risk of heart disease and stroke.

Rye intolerance is a condition in which the body has difficulty digesting rye, leading to gastrointestinal discomfort. Unlike rye allergy, which triggers an immune system reaction and can cause more severe symptoms, rye intolerance typically results in digestive issues after consuming rye or rye-based products.

AHSG (Alpha-2-HS-Glycoprotein), also known as fetuin-A, is a glycoprotein involved in various physiological processes, including inhibition of mineralization and regulation of insulin sensitivity. Elevated AHSG levels have been linked to insulin resistance and metabolic syndrome, suggesting its potential as a biomarker for these conditions.

Shrimp allergy is a common type of shellfish allergy, involving an immune reaction to proteins found in shrimp. It is one of the most common food allergies in adults and can cause a range of symptoms from mild to severe, including the risk of anaphylaxis. Shrimp allergy is typically lifelong and can be triggered by eating shrimp or even by inhaling steam from cooking shrimp.

ATP8B1 (ATPase Phospholipid Transporting 8B1) is a gene that encodes a phospholipid transporter found in the liver cell membrane. It helps maintain the lipid balance of cell membranes and bile. Mutations in ATP8B1 can lead to progressive familial intrahepatic cholestasis (PFIC), a group of inherited liver disorders.

Avocado intolerance is a condition in which individuals have difficulty digesting avocado, often resulting in gastrointestinal discomfort. Unlike avocado allergy, which triggers an immune system response and can lead to more severe reactions, avocado intolerance is limited to digestive symptoms that occur after avocado consumption.

Urinary leukocytes are white blood cells found in urine. They are typically absent or present in very small numbers, and higher levels often signal infection or inflammation in the urinary tract or kidneys. Their detection is an important marker for diagnosing urinary tract infections (UTIs) and other kidney-related conditions.

Non-HDL cholesterol is a measure of all cholesterol types that can contribute to arterial plaque buildup, including LDL (low-density lipoprotein), VLDL (very low-density lipoprotein), and other atherogenic lipid particles. It is calculated by subtracting HDL (high-density lipoprotein), or "good" cholesterol, from total cholesterol. Non-HDL cholesterol is considered a more comprehensive indicator of cardiovascular risk than LDL cholesterol alone, as it reflects all harmful cholesterol particles.

Ureaplasma is a group of tiny bacteria commonly found in the urogenital tracts of both men and women. They are part of the normal genital flora but can cause infection under certain conditions. Ureaplasma species, particularly Ureaplasma urealyticum and Ureaplasma parvum, are associated with conditions such as urethritis, pelvic inflammatory disease (PID), and infertility. While they can be sexually transmitted, they are not always classified strictly as STIs.

Fennel intolerance is a condition in which the body has difficulty digesting fennel, an aromatic herb often used in Mediterranean and Indian cuisine. It typically causes gastrointestinal discomfort and differs from fennel allergy, which involves an immune reaction and can trigger more severe symptoms. People with fennel intolerance usually experience digestive issues after consuming fennel or fennel-flavored foods.

Tapeworms are intestinal parasites that can affect humans and animals. These flat, segmented worms can grow to considerable lengths. They typically enter the body through the consumption of contaminated food or water. While tapeworm infections may sometimes be asymptomatic, they can also cause abdominal discomfort, diarrhea, and weight loss.

Threadworms (Strongyloides stercoralis) are tiny intestinal parasites that cause strongyloidiasis. They can be asymptomatic or lead to a variety of symptoms, including abdominal pain, diarrhea, and, in severe cases, malabsorption. Transmission occurs through skin contact with contaminated soil. These worms are notable for their ability to reproduce within the host, which can result in persistent, long-lasting infections.

New World hookworms (Necator americanus) are a type of parasitic worm commonly found in the Americas. These parasites attach to the intestinal walls of their hosts, causing chronic blood loss, anemia, and protein deficiency. The larvae can penetrate the skin from contaminated soil, putting individuals who come into contact with such environments at risk of infection.

King crab, a delicacy in seafood cuisine, is prized for its taste and texture. However, some individuals may experience king crab intolerance, which can affect their enjoyment of this seafood....

Pinworms (Oxyuris), also known as threadworms, are common intestinal parasites, especially in children. These small, white worms cause itching around the anus, disrupted sleep, and irritability due to their nighttime egg-laying. Infection spreads through the fecal-oral route, often by ingesting microscopic eggs from contaminated hands, surfaces, or food.

Dill intolerance is a condition in which individuals have difficulty digesting dill, an herb commonly used for its distinctive flavor in pickles, salads, and seafood dishes. It typically causes gastrointestinal discomfort and differs from a dill allergy, which triggers an immune response and can result in more severe symptoms. People with dill intolerance usually experience digestive issues after consuming dill or foods containing it.

Beef intolerance is a condition in which the digestive system reacts adversely to the consumption of beef. Unlike a beef allergy, which triggers an immune response and can be more severe, beef intolerance is related to difficulties in digesting or processing certain components of beef.

ATP1B3 (ATPase Na+/K+ Transporting Subunit Beta 3): ATP1B3 is a component of the Na⁺/K⁺ ATPase pump, which maintains cellular ion gradients essential for cell volume regulation and electrical activity. This subunit influences the pump’s activity and specificity, supporting muscle function, nerve signaling, and kidney filtration. Alterations in ATP1B3 may be linked to cardiovascular and neurological disorders.

Urine density, also called urine specific gravity, is a measure of the concentration of solutes in the urine. It reflects the kidney’s ability to concentrate or dilute urine and serves as an indicator of hydration status and kidney function. While normal values can vary, deviations may indicate dehydration, overhydration, or underlying kidney disorders.

Lamb intolerance is a condition in which the body has difficulty digesting lamb meat, resulting in gastrointestinal discomfort. Unlike a lamb allergy, which triggers an immune system reaction and may cause severe symptoms, lamb intolerance typically leads to digestive issues that occur after consuming lamb.

HORMAD1 (HORMA Domain-Containing Protein 1): HORMAD1 is a gene that encodes a protein containing a HORMA domain, which is involved in chromosome dynamics during meiosis. It plays a key role in regulating homologous chromosome pairing and segregation, contributing to genetic diversity and proper gamete formation.

Halibut intolerance is a condition in which individuals have difficulty digesting halibut, a flatfish commonly eaten as a seafood delicacy. It can cause gastrointestinal discomfort and differs from a halibut allergy, which triggers an immune system reaction and may result in more severe symptoms. People with halibut intolerance typically experience digestive issues after eating halibut or dishes prepared with it.

Kynurenine is a key metabolite in the breakdown of the essential amino acid tryptophan. It acts as a precursor to several important compounds, including neuroprotective kynurenic acid and neurotoxic quinolinic acid, and plays a crucial role in a range of physiological and pathological processes in the body.

Urinary nitrates are chemical compounds typically absent or present only in small amounts in urine. Their presence can indicate a bacterial infection, such as a urinary tract infection (UTI), since certain bacteria can convert urinary nitrite into nitrate. Nitrate testing is a common diagnostic method for detecting UTIs.

HPRT1 (Hypoxanthine Phosphoribosyltransferase 1): HPRT1 is an essential gene involved in purine metabolism. It catalyzes the conversion of hypoxanthine to inosine monophosphate (IMP), a key precursor for purine nucleotide synthesis. Mutations in HPRT1 can result in Lesch-Nyhan syndrome, a rare genetic disorder associated with neurological and behavioral abnormalities.

SERTAD2 (SERTA Domain Containing 2): SERTAD2 is a multifunctional protein that contains a SERTA domain, which is linked to cell cycle regulation. In addition to its role in cell cycle progression, SERTAD2 participates in key cellular processes such as DNA replication, DNA repair, and chromatin remodeling. Its interactions with various transcription factors and co-regulators make it an important regulator of gene expression.

Dermatophagoides pteronyssinus (D. pteronyssinus), commonly known as the European house dust mite, is a common indoor allergen. These microscopic organisms thrive in warm, humid environments and feed on organic matter such as shed human skin flakes. Their body fragments and waste products can provoke allergic reactions and asthma in sensitive individuals.

Catnip (Nepeta cataria) is a herbaceous plant from the mint family, best known for its stimulating effects on cats. While not typically consumed by humans, some individuals may experience catnip intolerance — a sensitivity to its compounds that can cause digestive discomfort. This differs from a catnip allergy, which involves an immune reaction and may trigger more severe symptoms.

Grass pollen allergies are a measure that reflects sensitivity to various grass species — including sweet vernal, orchard grass, common reed, and bent grass. These allergens can significantly affect individuals prone to allergic reactions, influencing respiratory health, eye irritation, and overall well-being. Understanding these allergies, recognizing symptoms, and applying effective management strategies can help reduce discomfort and improve quality of life during peak pollen seasons.

Carrot allergy is an allergic reaction triggered by specific proteins in carrots. Though uncommon, it can affect individuals with sensitivities to certain plant-based foods. It is often linked to Oral Allergy Syndrome (OAS), particularly in people allergic to birch or mugwort pollen, due to cross-reactive proteins.

KMO (Kynurenine 3-monooxygenase) is an enzyme that plays a key role in the kynurenine pathway, responsible for metabolizing the amino acid tryptophan. It helps regulate the balance of metabolites within this pathway, influencing processes that can affect brain health. KMO activity has been linked to neurological conditions such as Alzheimer’s disease, Huntington’s disease, and schizophrenia.

PKP4 (Plakophilin 4): PKP4 is a protein that supports cell–cell adhesion, particularly within desmosomes — specialized structures that link neighboring cells. It helps maintain tissue integrity, especially in areas exposed to mechanical stress. Mutations in PKP4 can disrupt this function, contributing to certain skin and cardiac disorders.

Grape intolerance is a condition in which the body has difficulty digesting grapes, leading to gastrointestinal discomfort. Unlike a grape allergy, which triggers an immune response and can cause severe reactions, grape intolerance typically results in digestive symptoms after consuming grapes or grape-derived products.

Urobilinogen in urine is a by-product of red blood cell breakdown, formed in the intestines from bilirubin and excreted in the urine. It is normally found in low concentrations and serves as an indicator of liver function and health. Abnormally high or low levels may indicate liver disease or blood-related conditions.

THADA (Thyroid Adenoma Associated): THADA is a gene associated with thyroid adenomas, a type of thyroid tumor. It may play a role in thyroid tumorigenesis and has been implicated in thyroid cancer development, making it a focus of ongoing research in thyroid diseases.

Pancreatic elastase is an enzyme produced by the pancreas that plays a key role in protein digestion. Measuring its levels in stool can provide important insights into pancreatic function. Because the enzyme remains stable in fecal matter, it serves as a reliable marker for assessing the exocrine function of the pancreas, especially in diagnosing pancreatic insufficiency.

SCAMP1 (Secretory Carrier Membrane Protein 1): SCAMP1 is a protein involved in membrane trafficking processes, particularly in the recycling of membrane proteins and in exocytosis. It plays a key role in cellular communication and the transport of substances within cells, which is essential for various cellular functions.

Allergies to seafood such as plaice, anchovy, and Alaska pollock occur when the immune system reacts to specific proteins in these fish. These reactions can cause a range of symptoms and may significantly affect diet and lifestyle. Understanding the triggers, symptoms, and management strategies is important for those living with these allergies.

Chicken intolerance is a condition in which the body has difficulty digesting chicken, resulting in digestive discomfort. Unlike a chicken allergy, which triggers an immune response and can cause more immediate and severe reactions, chicken intolerance typically leads to gastrointestinal symptoms after consumption.

COL11A1 (Collagen Type XI Alpha 1 Chain): COL11A1 is a gene that encodes a key component of type XI collagen, which is essential for the structure and integrity of connective tissue. Mutations in COL11A1 are linked to several connective tissue disorders, including some forms of Ehlers-Danlos syndrome and Stickler syndrome.

The quantitative determination of nitrogen (N) is a laboratory test that measures nitrogen levels in bodily excretions, typically urine or feces, to assess protein digestion and absorption. This test is essential for evaluating nutritional status, especially in clinical settings where protein-energy malnutrition or imbalances may be a concern. It provides key insights into metabolic functions related to protein turnover and can help diagnose conditions affecting protein metabolism, including kidney disease, malabsorption syndromes, and certain metabolic disorders.

Dientamoeba fragilis is a single-celled parasite that resides in the human gastrointestinal tract. It is linked to dientamoebiasis, a condition that may cause various digestive symptoms. Its exact mode of transmission and role in disease remain under investigation.

SLC22A5 (Solute Carrier Family 22 Member 5): SLC22A5 is a protein, also known as OCTN2, that functions as a key carnitine transporter in the body. It facilitates the cellular uptake of carnitine, a compound essential for moving fatty acids into mitochondria for energy production. This process is critical for energy metabolism in tissues such as the heart and muscles. Mutations in the SLC22A5 gene can result in primary carnitine deficiency, a condition marked by muscle weakness and cardiomyopathy, highlighting its vital role in metabolic health and energy balance.

Cucumber intolerance is a condition in which the body has difficulty digesting cucumber, often resulting in gastrointestinal discomfort. Unlike a cucumber allergy, which triggers an immune response and can cause more severe reactions, cucumber intolerance typically leads to digestive symptoms after consumption.

Baker’s yeast intolerance is a condition in which individuals have difficulty digesting baker’s yeast, often resulting in gastrointestinal discomfort. Unlike a baker’s yeast allergy, which triggers an immune response and can cause more severe reactions, intolerance is limited to digestive issues. Symptoms typically occur after consuming foods or drinks made with baker’s yeast.

ATXN1 (Ataxin 1): ATXN1 is a gene that encodes the ataxin-1 protein, which plays a role in neuronal function. Mutations in ATXN1, especially those involving expanded CAG repeats, lead to spinocerebellar ataxia type 1 (SCA1) — a neurodegenerative disorder marked by progressive loss of motor coordination and balance. Studying ATXN1 is important for understanding SCA1 and developing potential treatments for related neurological diseases.

GPR139 is a G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, especially in regions involved in regulating neurotransmitter systems and neuronal activity. It is thought to modulate neurotransmission, particularly dopamine and glutamate signaling, and may act as an inhibitory receptor by lowering cAMP levels and reducing neuronal excitability.

AMBRA1 (Autophagy and Beclin 1 Regulator 1): AMBRA1 is a key protein that regulates autophagy, the process by which cells degrade and recycle their components. It supports cell survival during stress by working with BECN1 (Beclin 1) to initiate autophagosome formation. Proper function of AMBRA1 is essential for cellular homeostasis, and its dysregulation has been associated with developmental disorders and neurodegenerative diseases.

ALX4 (ALX Homeobox 4): ALX4 is a transcription factor that plays a key role in skull and limb development. Mutations in this gene are linked to craniofacial malformations and skeletal abnormalities, underscoring its importance in bone formation and morphogenesis.

APEH (Acylaminoacyl-Peptide Hydrolase): APEH is an enzyme that plays a key role in protein turnover by degrading acetylated peptides. It is involved in processing damaged or misfolded proteins, helping to maintain protein homeostasis. Dysfunctions in APEH can impact neurodegenerative processes and the body’s response to oxidative stress.

SCARB1 (Scavenger Receptor Class B Member 1): SCARB1 is a protein that plays a key role in the selective uptake of cholesterol esters from high-density lipoprotein (HDL) particles. It is essential for lipid metabolism and reverse cholesterol transport. Variants in SCARB1 can affect cholesterol levels and have been linked to cardiovascular disease risk.

ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2): ALDH1A2 is an enzyme in the aldehyde dehydrogenase family that catalyzes the oxidation of retinaldehyde to retinoic acid, the active form of vitamin A. This conversion is essential for developmental processes such as embryogenesis, tissue patterning, and organ formation, as it regulates gene expression and cell differentiation through retinoic acid signaling. ALDH1A2 is highly expressed in developing tissues, including limb buds, the central nervous system, and sensory organs.

Palladium is a metal used in electronics, jewelry, and dental materials. While useful in various industries, high levels of inhalation or ingestion can be toxic, particularly in occupational settings. Exposure may cause respiratory, skin, and digestive issues, and some individuals may develop allergic reactions such as dermatitis.

Alaska pollock intolerance is a condition in which individuals have difficulty digesting Alaska pollock, a type of fish, resulting in gastrointestinal discomfort. Unlike an allergy to Alaska pollock, which triggers an immune system reaction and can cause more severe symptoms, intolerance typically leads to digestive issues after consumption.

Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium Chlamydia trachomatis. It can affect both men and women and may lead to serious, lasting damage to a woman’s reproductive system, increasing the risk of infertility. In some cases, it can also result in a potentially fatal ectopic pregnancy, where the pregnancy develops outside the womb.

KCTD1 (Potassium Channel Tetramerization Domain Containing 1): KCTD1 is a protein that interacts with potassium channels, influencing their activity. It plays important roles in cellular functions such as signal transduction and ion transport. Mutations in KCTD1 have been associated with developmental disorders, particularly affecting skin and hair.

Anti-Müllerian Hormone (AMH) is a hormone produced by the ovaries that indicates a woman’s ovarian reserve, reflecting the number of eggs remaining. It is commonly used to assess fertility potential and is an important marker in reproductive medicine.

AHCY: Encodes the enzyme adenosylhomocysteinase, which plays a key role in converting S-adenosylhomocysteine to homocysteine, an essential step in the body's methylation processes and detoxification.

Holotranscobalamin (holoTC), also known as active vitamin B12, is the form of vitamin B12 bound to transcobalamin, a transport protein in the blood. It is the only form that can be taken up by cells through receptor-mediated endocytosis, making it directly available for cellular functions. Measuring holoTC provides a more accurate indication of recent vitamin B12 status than total vitamin B12, as it reflects the fraction that is immediately available for use by the body.

Mussels intolerance is a condition in which the body has difficulty digesting mussels, often resulting in gastrointestinal discomfort. It differs from a mussels allergy, which involves an immune system reaction and can cause more severe symptoms. Individuals with mussels intolerance typically experience digestive issues after consuming this type of shellfish.

Flaxseed intolerance is a condition that reflects difficulty in digesting flaxseeds, small seeds valued for their rich nutrition and health benefits. It primarily affects the gastrointestinal tract, causing discomfort after consumption. Unlike a flaxseed allergy, which triggers an immune response and can be more severe, flaxseed intolerance mainly results in digestive symptoms when flaxseeds or flaxseed-containing foods are eaten.

Rucola (arugula/rocket) is a leafy green vegetable known for its distinctive peppery flavor and is commonly used in salads, sandwiches, and as a garnish. While generally well tolerated, some individuals may experience arugula intolerance, which can cause discomfort when consuming it.

NCOR1 (Nuclear Receptor Corepressor 1) is a protein that plays a key role in regulating gene expression and transcriptional repression. Located mainly in the cell nucleus, NCOR1 modulates the activity of nuclear receptors and other transcription factors. It functions as a corepressor for receptors such as thyroid hormone receptors (TRs), retinoic acid receptors (RARs), and peroxisome proliferator-activated receptors (PPARs). By recruiting histone deacetylases (HDACs) and other chromatin-modifying enzymes, NCOR1 helps form repressive chromatin structures, leading to reduced gene transcription.

TWIST1 (Twist Family BHLH Transcription Factor 1): TWIST1 is a gene that encodes a protein essential for embryonic development, particularly in guiding mesenchymal cell lineage determination. It is involved in craniofacial formation and is associated with Saethre-Chotzen syndrome — a congenital condition marked by craniosynostosis.

Tryptophan is an essential amino acid that supports sleep and mood. It helps the body produce serotonin, a neurotransmitter that influences sleep, emotions, and appetite. Found in foods like turkey, chicken, milk, and nuts, tryptophan plays a key role in relaxation, sleep, and overall mental well-being.

Rosemary intolerance is a condition that reflects the body’s inability to properly tolerate rosemary, a fragrant and aromatic herb widely used for its distinctive flavor and scent. While rosemary is commonly enjoyed in many dishes, individuals with this intolerance may experience discomfort or adverse reactions upon consumption.

The HSV-1 IgG antibody test measures the presence of antibodies against Herpes Simplex Virus type 1 (HSV-1) in the body. HSV-1 is commonly linked to oral herpes but can also cause genital infections. IgG antibodies usually develop a few weeks after initial infection and persist for life, indicating past or ongoing exposure. While this test does not show whether the infection is currently active, it helps confirm prior contact with the virus and may be clinically relevant when evaluating symptoms or before certain medical procedures.

Pollen from cypress trees, prevalent in the spring and fall. Known to cause hay fever and asthma symptom.

Fish commonly consumed and used in various culinary dishes. Cod allergies can provoke digestive symptoms and anaphylaxis.

Pollen from rye grass, a significant cause of hay fever and respiratory allergies during its pollen season.

Pollen from olive trees, typically causing hay fever and other respiratory allergies during blooming periods.

Stone fruit that can cause allergies ranging from oral allergy syndrome to severe reactions like anaphylaxis.

RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region): RBPJ is a key transcription factor in the Notch signaling pathway, which plays a critical role in regulating cell fate, differentiation, and development. Proper function of RBPJ is essential for tissue development and cell specialization, while dysregulation of RBPJ and Notch signaling is associated with various diseases, including cancers and developmental disorders.

Allergenic animal dander that can cause respiratory symptoms and skin reactions

LRFN5 (Leucine Rich Repeat and Fibronectin Type III Domain Containing 5): LRFN5 is a member of the LRFN family of proteins. It is involved in neuronal development and synaptic function, playing a role in the formation and maintenance of neural circuits. Dysfunctions in LRFN5 may contribute to neurodevelopmental disorders.

Taurine is an amino acid essential for heart muscle function, vision, and nerve health. It supports cardiovascular function, helps maintain healthy eyes, and contributes to nerve growth and activity. Taurine is naturally found in foods such as meat, fish, and dairy.

TRIB1 (Tribbles Pseudokinase 1): TRIB1 is a gene that encodes a pseudokinase protein belonging to the Tribbles family. TRIB1 plays key roles in regulating multiple cellular signaling pathways, including those involved in growth, metabolism, and inflammation. It has been linked to lipid metabolism, cardiovascular health, and cancer, with its complex functions continuing to be an active area of research.

Allergenic protein found in the skin, saliva, and urine of cats, which can cause respiratory issues and asthma.

MITF (Melanocyte Inducing Transcription Factor): MITF is a key regulator that reflects the role of MITF in the development and function of melanocytes, the cells responsible for pigment production. It is essential for normal pigmentation, and mutations in MITF can lead to pigmentary disorders and increase the risk of melanoma, a type of skin cancer. MITF also contributes to the development of certain retinal cells and is implicated in Waardenburg syndrome.

MME, also known as Membrane Metallo-Endopeptidase or neprilysin, is a zinc-dependent metalloprotease enzyme that plays a key role in the regulation of peptide signaling molecules. It is primarily located on the cell membrane of various cell types, including neurons, endothelial cells, and immune cells. MME is especially important for degrading peptides involved in blood pressure regulation, such as bradykinin and atrial natriuretic peptide (ANP), converting them into inactive fragments and helping maintain cardiovascular homeostasis.

TMEM171 (Transmembrane Protein 171): TMEM171 is a gene that encodes a transmembrane protein. While its specific functions are not yet fully understood, transmembrane proteins generally play important roles in cell signaling, transport of molecules across membranes, and cellular communication. Further research is needed to clarify the precise roles of TMEM171 in cellular processes.

Grass pollen that is a significant cause of seasonal allergies, especially in late spring and early summer.

Anti-deamidated gliadin antibodies (anti-DGP) are immune proteins produced in response to deamidated fragments of gliadin, a component of gluten. These antibodies, especially when both IgA and IgG subtypes are measured, provide high sensitivity and specificity for detecting celiac disease. Elevated levels indicate an immune response to gluten, often before intestinal damage becomes apparent. Testing for anti-DGP is particularly useful in individuals with suspected celiac disease, including those who have been on a gluten-free diet for a short time. Measuring both IgA and IgG allows for better detection across different immune profiles.

Asparagus intolerance is a condition in which individuals have difficulty digesting asparagus, resulting in gastrointestinal discomfort. Unlike an asparagus allergy, which triggers an immune response and may cause more severe reactions, asparagus intolerance typically leads to digestive symptoms after consumption.

HPV (Human Papillomavirus): HPV is a group of over 200 viruses, with some types being sexually transmitted and linked to health issues like genital warts and cancers, particularly cervical cancer. The high-risk types, especially HPV-16 and HPV-18, are strongly associated with cancers of the cervix, throat, anus, and penis. While most HPV infections are asymptomatic and resolve on their own, persistent infections can lead to cancer. Vaccination is available to protect against the most dangerous strains, and regular screening is important for early detection and prevention.

Apple allergy is an allergic reaction to proteins found in apples, often linked to Oral Allergy Syndrome (OAS). It commonly occurs in people allergic to birch pollen, as similar proteins in apples can trigger cross-reactivity. Symptoms can range from mild oral discomfort to more pronounced reactions, though severe cases are uncommon.

Tyrosine is an amino acid that supports brain function and mood. It helps produce neurotransmitters such as dopamine, which influence mood, focus, and mental alertness. Found in foods like cheese, soy products, fish, and poultry, tyrosine is important for emotional well-being, stress response, and thyroid function.

Vanillylmandelic acid (VMA) is a metabolite formed from the breakdown of catecholamines such as adrenaline, noradrenaline, and dopamine. It is used as a clinical marker to assess catecholamine activity, with levels typically measured in urine. Various factors, including certain foods and medications, can influence VMA levels.

Free testosterone refers to the fraction of testosterone in the bloodstream that is not bound to proteins like sex hormone-binding globulin (SHBG) or albumin. Unlike bound testosterone, free testosterone is biologically active and readily available to interact with cells, making it a key indicator of hormonal activity in the body. It plays a vital role in regulating libido, energy levels, muscle strength, and mood in both men and women.

NMRK1 (Nicotinamide Riboside Kinase 1): NMRK1 is an enzyme that plays a key role in the NAD+ biosynthesis pathway by catalyzing the conversion of nicotinamide riboside to nicotinamide mononucleotide. NAD+ is essential for energy metabolism, DNA repair, and cellular signaling. Through its role in NAD+ production, NMRK1 is important for maintaining cellular energy balance and genomic stability, with implications for aging, metabolic disorders, and conditions linked to NAD+ depletion.

Eicosapentaenoic acid (EPA) is a measure that reflects the presence of an essential Omega-3 fatty acid in the body, primarily obtained from fish and seafood. EPA is known for its anti-inflammatory properties and plays a vital role in supporting cardiovascular health and maintaining a balanced range of bodily functions.

JAK2 (Janus Kinase 2): JAK2 is a gene that encodes a kinase enzyme belonging to the Janus kinase (JAK) family. JAK2 plays a key role in cytokine signaling pathways and is essential for the activation of immune and blood-forming (hematopoietic) cells. Mutations in JAK2 are linked to blood disorders, including polycythemia vera and other myeloproliferative neoplasms.

Yolk intolerance is a condition that reflects difficulty in digesting egg yolks. Unlike an egg allergy, which triggers an immune system response and can cause severe reactions, yolk intolerance primarily leads to digestive discomfort. Individuals with this intolerance often experience gastrointestinal symptoms after consuming egg yolks.

TRPM6 (Transient Receptor Potential Cation Channel Subfamily M Member 6): TRPM6 is a channel that plays a key role in magnesium (Mg) absorption and homeostasis. It is essential for maintaining proper magnesium balance in the body, and mutations in TRPM6 can result in hypomagnesemia with secondary hypocalcemia, a condition marked by low magnesium and calcium (Ca) levels in the blood.